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1. Log in to your Plesk account.
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2. Go to Websites & Domains > Click on the Pull icon >> Choose Backup & Restore.

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3. Under Backup Manager, click on Back Up.

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4. Choose the backup type.

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5. Checkmark Exclude specific files from the backup.

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Enter the path of the file you want to exclude, such as:
/httpdocs/directory/filename.jpg
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To exclude a whole directory, enter:
/httpdocs/images
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To exclude only specific extensions such as PNG, enter:
/httpdocs/images/*.png
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6. Confirm with OK. The backup will start generating in the background. At this point, you can navigate away from the page.